Searchable abstracts of presentations at key conferences in endocrinology

ea0099rc12.1 | Rapid Communications 12: Diabetes, Obesity, Metabolism and Nutrition | Part II | ECE2024

Effects of semaglutide, Peptide YY3-36 and empagliflozin on metabolic dysfunction associated fatty steatotic liver disease in diet-induced obese rats with chronic nitric oxide synthase-inhibition

Geiger Niklas , Kloock Simon , Gerner Jana , Landthaler Aisha-Nike , Nickel Alexander , Kohlhaas Michael , Geier Andreas , Fassnacht Martin , Dischinger Ulrich

Background and Aims: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a common comorbidity of obesity. In this study, we sought to determine hepatic metabolic and mitochondrial effects of the Glucagon-like Peptide-1-agonist semaglutide, the sodium-glucose linked transporter 2-inhibitor empagliflozin and Peptide YY3-36 in diet-induced obese rats with additional chronic inhibition of nitric oxide synthase via Nω-nitro-L-arginine meth...